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Blood Reviews
Volume 21, Issue 6
, Pages 327-348
, November 2007
Transfusion-related immunomodulation (TRIM): An update
References
- Blood transfusion induced changes in cell-mediated lympholysis: to immunize or not to immunize. J Immunol. 1991;147:3348–3352
- Immunomodulation by blood transfusions. Vox Sang. 2000;78:273–275
- New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs. Ann Surg. 2002;236:667–675
- . T-cell costimulatory pathways in allograft rejection and tolerance. Immunol Rev. 2003;196:85–108
- . Costimulatory signals necessary for induction of T cell proliferation. Transplantation. 1990;49:768–772
- . Immunological aspects of blood transfusions. Transpl Immunol. 2002;10:183–190
- . Mechanisms of transfusion-induced immunosuppression. Transfusion. 1990;30:651–658
- . Mechanisms of transfusion-associated immunosuppression. Curr Opin Hematol. 1994;1:457–461
- Effect of blood transfusions on subsequent kidney transplants. Transplant Proc. 1973;5:253–259
- . Red blood cells for cancer patients. Lancet. 1981;2:363
- Multiple blood transfusions reduce the recurrence rate of Crohn’s disease. Dis Colon Rectum. 1989;32:749–753
- . Controlled trial of treatment of recurrent spontaneous abortion by immunization with paternal cells. Lancet. 1985;1:941–943
- In: Vamvakas EC, Blajchman MA editor. Immunomodulatory Effects of Blood Transfusion. Bethesda, MD: AABB Press; 1999;295 pp.
- . Biologic effects of leukocytes present in transfused cellular blood products. Blood. 1994;84:1705–1721
- . Deleterious clinical effects of transfusion-associated immunomodulation: fact or fiction?. Blood. 2001;97:1180–1195
- . Effects of transfusion on immune function: cancer recurrence and infection. Arch Pathol Lab Med. 1994;118:371–379
- . Blood transfusions and postoperative septic complications. Transfusion. 1994;34:714–727
- . Deleterious clinical effects of transfusion immunomodulation: proven beyond reasonable doubt. Transfusion. 2005;45(August Suppl.):33S–39S
- . Deleterious clinical effects of transfusion immunomodulation: proved beyond reasonable doubt. Transfusion. 2006;46:492–494
- Beneficial effect of leukocyte depletion of transfused blood on post-operative complications in patients undergoing cardiac surgery: A randomized clinical trial. Circulation. 1998;97:562–568
- Double-blind, randomized controlled trial on the effect of leukocyte-depleted erythrocyte transfusions in cardiac valve surgery. Circulation. 2004;109:2755–2760
- . Prestorage leukoreduction of red cells in elective cardiac surgery: Results of a double-blind randomized controlled trial. Blood. 2004;104:112a;(abstract)
- . Evolving concepts in the pathogenesis of postinjury multiple-organ failure. Surg Clin North Am. 1995;75:257–277
- . Role of neutrophils in generalized reperfusion injury associated with resuscitation from shock. Surgery. 1989;106:509–516
- . Multiple-organ failure: Inflammatory priming and activation sequences promote autologous tissue injury. J Trauma. 1990;30:S44–S49
- . Postinjury neutrophil priming and activation states: Therapeutic challenges. Shock. 1995;3:157–166
- Partial characterization of lipids that develop during the routine storage of blood and prime the neutrophil NADPH oxidase. J Lab Clin Med. 1994;124:684–694
- . Possible mechanisms of allogeneic blood transfusion-associated postoperative infection. Transf Med Rev. 2002;16:144–160
- . The before/after study design in transfusion medicine: Methodologic considerations. Transf Med Rev. 2002;16:296–303
- . Molecular genetic basis for the antiidiotypic antibody response associated with successful renal allograft survival in humans. Transplant Proc. 1991;23:1059–1062
- . Unusual kinetics of white cell clearance in transfused mice. Transfusion. 1995;35:145–149
- . Apoptosis, TGF-beta, and transfusion-related immunosuppression: Biologic versus clinical effects. Transfusion Apheresis Sci. 2003;29:127–129
- . Induction of humoral immune tolerance to major histocompatibility complex antigens by transfusions of UV-B irradiated leukocytes. Blood. 1996;88:4375–4382
- . Identification of the blood component responsible for increased susceptibility to gut-derived infection. Transfusion. 1993;33:458–465
- . Allogeneic blood transfusion-induced enhancement of tumor growth: two animal models showing amelioration by leukodepletion and passive transfer using spleen cells. Blood. 1993;81:1880–1882
- Blood transfusion and immunomodulation: a possible mechanism. Vox Sang. 1993;65:18–24
- Clark DA, Gorczynski RM, Blajchman MA. Transfusion-related immunomodulation due to blood dendritic cells expressing the CD200 tolerance-signaling molecules and alloantigen: Tumor growth is stimulated by TGFβ from suppressor-cell induction. Submitted for publication.
- . CD200 and membrane protein interactions in the control of myeloid cells. Trend Immunol. 2003;23:285–290
- . The same immunoregulatory molecules contribute to successful pregnancy and transplantation. Amer J Reprod Immunol. 2002;48:18–26
- . TGF-β in infections and infectious disease. Microbes and Infection. 1999;1:1313–1325
- Mechanisms of prior blood transfusion-cyclosporine-induced tolerance: a potential role for immune-cellular chimerism. Transplant Proc. 1991;23:147–148
- . Mononuclear cell microchimerism and the immunomodulatory effect of transfusion. Transfusion. 1994;34:1007–1012
- . Blood transfusion enhances production of T-helper-2 cytokines and transforming growth factor beta in humans. Clin Sci (Lond). 1996;91:519–523
- Blood transfusion and total joint replacement surgery: T-helper 2 cytokine secretion and clinical outcome. Transf Med. 1998;8:195–204
- . Transfusion-associated microchimerism: a new complication of blood transfusions in severely ill patients. Semin Hematol. 2007;44:24–31
- . Survival of donor leukocyte subpopulations in immunocompetent transfusion recipients: frequent long-term microchimerism in severe trauma patients. Blood. 1999;93:3127–3139
- Survival of transfused donor white blood cells in HIV-infected recipients. Blood. 2001;98:272–279
- High-level long-term white-blood-cell microchimerism after transfusion of leukoreduced blood components to patients resuscitated after severe traumatic injury. Transfusion. 2005;35:1280–1290
- Leukoreduction of blood transfusions does not diminish transfusion-associated microchimerism in trauma patients. Transfusion. 2006;46:1863–1869
- . The effects of leukoreduced blood transfusion on infection risk following injury: A randomized controlled trial. Shock. 2006;26:342–347
- Time-dependent, spontaneous release of white cell- and platelet-derived bioactive substances from stored human blood. Transfusion. 1996;36:960–965
- . Histamine-induced inhibition of neutrophil chemotaxis and T-lymphocyte proliferation in man. Allergy. 1992;47:624–629
- . Human eosinophil cationic proteins (ECP and EPX) and their suppressive effects on lymphocyte proliferation. Immunobiology. 1986;171:1–13
- Soluble HLA Class I, HLA Class II, and Fas ligand in blood components: a possible key to explain the immunomodulatory effects of allogeneic blood transfusion. Blood. 1999;93:1770–1777
- ;Soluble human MHC class I molecules induce soluble Fas-ligand secretion and trigger apoptosis in activated CD8+ Fas (CD95)+ T lymphocytes. Intern Immunol. 2000;12:195–203
- Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. Nature. 1998;396:699–703
- . Death receptors: Signaling and modulation. Science. 1998;281:1305–1308
- Immunologic changes following transfusion of autologous or allogeneic buffy-coated-poor versus leukocyte-depleted blood in patients undergoing arthroplasty. I. Proliferative T-cell responses and T-helper/T-suppressor cell balance. Transfusion. 1999;39:1089–1096
- Immunologic changes following transfusion of autologous or allogeneic buffy-coat-poor versus leukocyte-depleted blood transfusions in patients undergoing arthroplasty. II. Activation of T-cells, macrophages and cell-mediated lympholysis. Transfusion. 2000;40:821–827
- Transfusion. 1997;37:264–268
- . Effects of leukocyte depletion on the formation of anaphylatoxins in stored whole blood. Infusionsther Transfusionmed. 1992;19:242–244
- . Growth enhancement of established tumors by allogeneic blood transfusion in experimental animals and its amelioration by leukodepletion: the importance of timing of the leukodepletion. Blood. 1994;84:344–348
- Transforming growth factor-beta-1 in supernatants from stored red blood cells inhibits neutrophil locomotion. Blood. 2003;102:1100–1107
- Ottonello L, Ghio M, Contini P, et al. RBC transfusion induces a sustained inhibition of neutrophil chemotaxis by stimulating in vivo production of TGF-β-1 by neutrophils. Role of the immunoglobulin-like transcript 1 (ILT1), sFasL, and sHLA-I. Transfusion 2007;47 (In press).
- . Peptide-mediated immunosuppression. Curr Opin Immunol. 1997;9:669–675
- . Induction of tolerance toward rat cardiac allografts by treatment with allochimeric class I MHC antigen and FTY720. Transplantation. 1997;64:1407–1414
- . Induction of tolerance by intrathymic inoculation of alloantigen. Curr Opin Immunol. 1996;8:704–709
- Postoperative infection and natural killer cell function following blood transfusion in patients undergoing elective colorectal surgery. Br J Surg. 1992;79:513–516
- Blood transfusion and prognosis in colorectal cancer. N Engl J Med. 1993;328:1372–1376
- Beneficial effect of autologous blood transfusion on infectious complications after colorectal cancer surgery. Lancet. 1993;342:1328–1333
- Randomized controlled trial comparing transfusion of leucocyte-depleted or buffy-coat-depleted blood in surgery for colorectal cancer. Lancet. 1994;344:573–578
- . Blood transfusion with autologous and leukocyte-depleted or standard allogeneic red blood cells and the immune response to open-heart surgery. Anesth Analg. 1994;79:654–660
- Randomized comparison of leucocyte-depleted versus buffy-coat-poor blood transfusion and complications after colorectal surgery. Lancet. 1996;348:841–845
- . The clinical advantages of autologous transfusion: A randomized, controlled study after knee replacement. J Bone Joint Surg Br. 1997;79:630–632
- . Autologous blood transfusion: The benefits for the patient undergoing abdominal aortic aneurysm repair. J Vasc Nurs. 1997;15:111–115
- Prestorage leukocyte filtration may reduce leukocyte-derived bioactive substance accumulation in patients operated for burn trauma. Burns. 1999;25:162–170
- Randomized trial comparing packed red cell blood transfusion with and without leukocyte depletion for gastrointestinal surgery. Am J Surg. 1998;176:462–466
- Leukocyte-depletion of blood components does not significantly reduce the risk of infectious complications: Results of a double-blind, randomized study. Int J Colorectal Dis. 2001;16:147–153
- . Autologous blood transfusion in total knee replacement surgery. Br J Anaesth. 2001;86:669–673
- Leukocyte-reduced red blood cell transfusions in patients with anemia and human immunodeficiency virus infection. JAMA. 2001;285:1592–1601
- Autologous versus allogeneic transfusion in aortic surgery: A multicenter randomized clinical trial. Ann Surg. 2002;235:145–151
- A prospective, randomized clinical trial of universal WBC reduction. Transfusion. 2002;42:1114–1122
- Effect of WBC reduction of transfused RBCs on postoperative infection rates in cardiac surgery. Transfusion. 2002;42:1127–1134
- Effects of transfusion with red cells filtered to remove leukocytes: Randomized controlled trial in patients undergoing major surgery. BMJ. 2004;328:1281–1284
- Leukocyte-reduced blood in open-heart surgery patients: Effects on outcome. Transfusion. 2002;42(Suppl):5S
- Blood transfusion-modulated tumor recurrence: first results of a randomized study of autologous versus allogeneic blood transfusion in colorectal cancer surgery. J Clin Oncol. 1994;12:1859–1867
- . Skin cancer and immunosuppression. Lancet. 1973;i:1290–1291
- . Transfusion-associated cancer recurrence and infection: Meta-analysis of the randomized controlled clinical trials. Transfusion. 1996;36:175–186
- . Autologous transfusion and other approaches to reduce allogeneic blood exposure. In: Contreras M editors. New Aspects of Blood Transfusion. Baillére’s Best Practice and Research in Clinical Haematology. Vol. 13:London, UK: WB Saunders; 2000;p. 533–547
- . Reactivation of latent CMV in the rat. Transplant Proc. 1991;23(Suppl.3):22–24
- . Early transfusion and length of survival in acquired immune deficiency syndrome: Experience with a population receiving medical care at a public hospital. Transfusion. 1993;33:111–118
- Transfusion of blood components to persons infected with human immunodeficiency virus type 1: Relationship to opportunistic infection. Transfusion. 1994;34:48–53
- . Blood transfusion to AIDS patients: Relationship to opportunistic infection. Transfusion. 1994;34:740
- . Meta-analysis of randomized controlled trials comparing the risk of postoperative infection between recipients of allogeneic and autologous blood transfusion. Vox Sang. 2002;83:339–346
- . White-blood-cell-containing allogeneic blood transfusion and postoperative infection or mortality: An updated meta-analysis. Vox Sang. 2007;92:224–232
- Diversity and heterogeneity [monograph on the Internet]. Oxford: the Cochrane Collaboration; c2002 [accessed 2006 April 13]. Available from: http://www.cochrane-net.org/openlearning/HTML/mod13-5.htm.
- Clinical outcomes following institution of universal leukoreduction of blood transfusions for premature infants. JAMA. 2003;289:1950–1956
- Stored red blood cells selectively activate human neutrophils to release IL-8 and secretory PLA2. Shock. 2000;13:29–33
- . Transfusion-related acute lung injury. Blood. 2005;105:2266–2273
- Supernatant from stored red cells activates neutrophils. Transfus Med. 1998;8:49–56
- Resuscitation with a blood substitute abrogates pathologic postinjury neutrophil cytotoxic function. J Trauma. 2001;50:449–455
- The role of leukocyte depletion in reducing injury to myocardium and lung during cardiopulmonary bypass. ASAIO J. 1995;41:M291–M294
- Leukocyte depletion results in improved lung function and reduced inflammatory response after cardiac surgery. J Thorac Cardiovasc Surg. 1996;112:494–500
- Leukocyte-depleted reperfusion of transplanted human hearts prevents ultrastructural evidence of reperfusion injury. J Surg Res. 1992;52:298–308
- Impact of blood transfusions on inflammatory mediator release in patients undergoing cardiac surgery. Chest. 1999;116:1233–1239
- . Determinants of prolonged mechanical ventilation after coronary artery bypass grafting. Ann Thorac Surg. 1996;62:1164–1171
- . Allogeneic blood transfusion and postoperative duration of mechanical ventilation: Effects of red cell supernatant, platelet supernatant, plasma components, and total transfused fluid. Vox Sang. 2002;82:141–149
- Role of blood transfusion in organ system failure following major abdominal surgery. Ann Surg. 1986;203:275–281
- Early predictors of postinjury multiple-organ failure. Arch Surg. 1994;129:39–45
- Factors related to multiple-organ system failure and mortality in a surgical intensive care unit. Nephrol Dial Transplant. 1994;9(Suppl.4):172S–178S
- Oxygen delivery is an important predictor of outcome in patients with ruptured aortic aneurysms. Ann Surg. 1998;227:726–732
- The effect of transfusion on pulmonary function in patients with thalassemia major. Pediatr Pulmonol. 1994;18:139–143
- Do blood transfusions improve outcomes related to mechanical ventilation?. Chest. 2001;119:1850–1857
- . Transfusion and postoperative pneumonia in coronary artery bypass graft surgery: effect of the length of storage of transfused red cells. Transfusion. 1999;39:701–710
- . The impact of storage time of transfused blood on postoperative infectious complications in rectal cancer surgery. Scand J Gastroenterol. 2000;35:212–217
- . Increased rate of infection associated with transfusion of old blood after severe injury. Arch Surg. 2002;137:711–716
- Influence of erythrocyte concentrate storage time on postsurgical morbidity in cardiac surgery patients. Anesthesiology. 2003;98:815–822
- Age of transfused blood is an independent risk factor for postinjury multiple-organ failure. Am J Surg. 1999;178:540–572
- . Association of mortality with age of blood transfused in septic ICU patients. Can J Anaesth. 1997;44:1256–1261
- The association between duration of storage of transfused red blood cells and morbidity and mortality after reoperative cardiac surgery. Anesth Analg. 2006;103:15–20
- . Effects of storage time on the prognosis of coronary artery bypass graft patients. Transfusion. 2006;46:1712–1718
- . Clinical consequences of red-cell storage in the critically ill. Transfusion. 2006;46:2014–2027
- The effect of universal leukodepletion of packed red blood cells on postoperative infections in high-risk patients undergoing abdominal aortic surgery. Anesth Analg. 2002;94:529–537
- The effect of universal leukoreduction on postoperative infections and length of stay in elective orthopedic and cardiac surgery. Transfusion. 2004;44:489–500
- Clinical outcomes following institution of the Canadian universal leukoreduction program for red blood cell transfusions. JAMA. 2003;289:1941–1949
- . A case-control study of the impact of WBC reduction on the cost of hospital care for patients undergoing coronary artery bypass graft surgery. Transfusion. 2002;42:1123–1126
- Leukocyte-reduced transfusions in cardiac surgery: Results of an implementation trial. Am J Clin Pathol. 2002;118:376–381
- . White-blood-cell containing allogeneic blood transfusion, postoperative infection, and mortality: A meta-analysis of observational, “before-and-after” studies. Vox Sang. 2004;86:111–119
- . Clinical studies of blood transfusion and cancer. In: Vamvakas EC, Blajchman MA editor. Immunomodulatory effects of allogeneic blood transfusion. Bethesda, MD: AABB Press; 1999;p. 145–190
- . Perioperative blood transfusion and outcome after resection for colorectal carcinoma. Br J Surg. 1993;80:427–432
- . Perioperative blood transfusion and cancer recurrence: Meta-analysis for explanation. Transfusion. 1995;35:760–768
- . Universal white-cell reduction: The case for and against. Transfusion. 2001;41:691–712
PII: S0268-960X(07)00035-5
doi: 10.1016/j.blre.2007.07.003
© 2007 Elsevier Ltd. All rights reserved.
« Previous
Blood Reviews
Volume 21, Issue 6
, Pages 327-348
, November 2007
