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Blood Reviews
Volume 22, Issue 1
, Pages 33-52
, January 2008
Fetal and neonatal alloimmune thrombocytopenia: progress and ongoing debates
References
- . Fetal thrombocytopenia and its relation to maternal thrombocytopenia. N Engl J Med. 1993;329:1463–1466
- Kjeldsen-Kraghl J, Killie MK, Aune B, et al. An intervention program for reducing morbidity and mortality associated with neonatal and allo-immune thrombocytopenia purpura (NAITP). Presented at the 8th European Symposium on Platelet and Granulocyte Immunobiology 2004; Rust, Australia.
- Prospective epidemiologic study of the outcome and cost-effectiveness of antenatal screening to detect neonatal alloimmune thrombocytopenia due to anti-HPA-1a. Transfusion. 2005;45(12):1945–1956
- . Nomenclature of platelet-specific antigens. Transfusion. 1990;30:477–481
- ABH antigens on human platelets: expression on the glycosyl phosphatidylinositol-anchored protein CD109. J Lab Clin Med. 1998;132:142–148
- . Maternal anti-HLA antibodies and neonatal thrombocytopenia. Lancet. 1981;1(8233):1313
- The role of HLA antibodies in neonatal thrombocytopenia: a prospective study. Tissue antigens. 1996;47:206–211
- Han KS, Song EY, Park MH. Neonatal alloimmune thrombocytopenia due to HLA antibodies. International Journal of Hematology 2002; 76 (suppl) 1:361–3.
- Serologic analysis of three cases of neonatal alloimmune thrombocytopenia associated with HLA antibodies. Transfusion. 2003;43(7):908–917
- HLA antibodies and neonatal alloimmune thrombocytopenia. Acta Haematol. 2004;111(4):215–220
- . ICSH/ISBT Working Party on Platelet Serology. Nomenclature of platelet-specific antigens. Vox Sang. 1990;58:176–177
- . The molecular immunology of human platelet proteins. Blood. 1992;1386–1404
- . Alloimmune thrombocytopenia. Clin Obstet Gynecol. 1999;42:335–348
- . Nomenclature of human platelet alloantigens: a problem with the HPA system?. Blood. 1994;83:1447–1451
- . Alloimmune thrombocytopenia. Curr Stud Hematol Blood Transfus. 1988;55:87–96
- 348 cases of suspected neonatal alloimmune thrombocytopenia. Lancet. 1989;1:363–366
- . Fetal thrombocytopenia: a retrospective survey of 5194 fetal blood samplings. Blood. 1995;84:1851–1856
- Neonatal immune thrombocytopenia due to allo- or antoantibodies. Platelets. 1994;5:53–58
- . Alloimmune thrombocytopenia of the newborn: neurodevelopmental sequele. Am J Perinatol. 1996;13:211–215
- . Neonatal thrombocytopenia: incidence, serological and clinical observations. Am J Perinatol. 1997;14:4154–4418
- The natural history of fetomaternal alloimmunization to the platelet–specific antigen HPA-1a (PlA1, Zwa) as determined by antenatal screening. Blood. 1998;92:2280–2287
- . Neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies; the level of maternal antibodies predicts the severity of thrombocytopenia in the newborn. BJOG. 2000;107:691–694
- . Neonatal and maternal thrombocytopenia: incidence and immune background. Eur J Haematol. 2000;64:42–46
- HPA-5b (Bra) neonatal alloimmune thrombocytopenia: clinical and immunological analysis of 39 cases. Br J Haematol. 1991;78:425–429
- Maternal alloimmunization against fetal platelet antigens: A prospective study. Br J Haematol. 1995;90:655–660
- . IgG titer, subclass and light-chain phenotype of pregnancy-induced HPA-5b antibodies that cause or do not cause alloimmune thrombocytopenia. Transfusion. 1999;39:379–382
- . HPA-5b (Bra) neonatal alloimmune thrombocytopenia in Quebec: incidence and clinical outcome in 31 cases. Transfusion. 2004;44(6):363–365
- . Anti-HPA-3A induces severe neonatal alloimmune thrombocytopenia. J Pediatr. 2001;138(6):862–867
- . Severe neonatal alloimmune thrombocytopenia caused by antibodies to human platelet antigen 3a (Baka) detectable only in whole platelet assays. Transfusion. 2003;43(10):1398–1402
- . Maternal alloimmunization against the rare platelet-specific antigen HPA-9b (Max a) is an important cause of neonatal alloimmune thromobocytopenia. Transfusion. 2005;45(9):1487–1495
- Anti-HPA-9bw (Maxa) fetomaternal alloimmunization, a clinically severe neonatal thrombocytopenia: difficulties in diagnosis and therapy and report on eight families. Transfusion. 2005;45(11):1799–1803
- . Relevance of the HPA-15 (Gov) polymorphism on CD109 in alloimmune thrombocypenic syndromes. Transfusion. 2005;45(3):366–373
- . Isoimmunization against CD36 (glycoprotein IV): description of four cases of neonatal isoimmune thrombocytopenia and brief review of the literature. Transfusion. 2002;42(9):1173–1179
- Two sibling cases of hydrops fetalis due to alloimmune anti-DB36 (Nak a) antibody. J Thromb Haemost. 2006;95(2):267–271
- . Determination of platelet antigens and glycoproteins in the human fetus. Blood. 1986;68:488–492
- . Very early intracranial Hemorrhage in alloimmune fetal thrombocytopenia. Lancet. 1990;336:310
- . Antenatal management of severe feto-maternal thrombocytopenia: HLA incompatability may affect responses to fetal platelet transfusions. Blood. 1993;81:2174–2179
- . Is there a relationship between anti-HPA-1a concentration and severity of neonatal alloimmune thrombocytopenia?. Immunohematol. 2005;21(3):102–109
- . Predictive value of sequential maternal anti-HPA-1a antibody concentrations for the severity of fetal alloimmune thrombocytopenia. J Thromb Haemost. 2006;4(3):628–637
- . Maternal human platelet antigen-1a antibody level correlates with the platelet count in the newborns: a retrospective study. Transfusion. 2007;47(1):55–58
- . Serological and genetical studies on a platelet antigen (Zw). Vox Sang. 1959;4:161–169
- . Platelet and leukocyte isoantigens and their antibodies: serologic, physiologic, and clinical studies. Prog Hematol. 1964;4:222–304
- . Should all pregnant women be tested for their platelet PLA (Zw, HPA-1) phenotype?. Br J Haematol. 1994;86:1–5
- . Alloimmunization to the PLA1 platelet antigen: results of a prospective study. Br J Haematol. 1990;74:209–215
- . Screening primiparous women and newborns for fetal/neonatal alloimmune thrombocytopenia: A prospective comparison of effectiveness and costs. Am J Perinatol. 1996;13:423–431
- . HLA-B8 antigen and anti-PlA1 alloimmunization. Tissue Antigens. 1981;18:66–68
- . Immunogenicity of an immune response to the platelet antigen Zw(a) is strongly associated with HLA-B8 and DR3. Tissue Antigens. 1985;26:71–76
- . HLA-B8 antigen and anti-PlA1 alloimmunization. Tissue Antigens. 1982;19:154–156
- . HLA antigens and maternal antibodies in allo-immune neonatal thrombocytopenia. Tissue Antigens. 1983;21:351–359
- . Is HLA-DR3 a risk factor in PLA1-negative pregnant women?. Curr Stud Hematol Blood Transfus. 1986;52:78–86
- HLA-DRw52a is involved in alloimmunization against PLA1 antigen. Hum Immunol. 1990;27:73–79
- . The immune response to the HPA-1a antigen: association with HLA-DRw52a. Transfus Med. 1991;1:55–62
- Alloimmunization to platelet antigen HPA-1a (PlA1) is strongly associated with both HLA-DRB3∗0101 and HLA-DQB1∗0201. Hum Immunol. 1992;34:107–114
- . Alloimmunization against the platelet specific Zwa antigen, resulting in neonatal alloimmune thrombocytopenia or post-transfusion purpura, is associated with supertypic DRw52 antigen including DR3 and DRw6. Hum Immunol. 1986;4:222–304
- . An integrin polymorphism that defines reactivity with alloantibodies generates an anchor for MHC class II peptide binding. J Immunol. 1997;158:3221–3226
- . Neonatal alloimmune thrombocytopenia due to fetomaternal Zwb incompatibility. Vox Sang. 1986;50:94–96
- Maternal DRB1∗1501, DQA1∗0102, DQB1∗0602 haplotype in fetomaternal alloimmunisation against human platelet alloantigen HPA-6B (GPIIIa-Gln489). Tissue Antigens. 1997;50:113–118
- . Fetal alloimmune thrombocytopenia. N Engl J Med. 1997;337(1):22–26
- . The Immune Thrombocytopenia Working Group. Frequency of immune thrombocytopenia in newborns: A prospective study. Blood. 1997;89:4402–4406
- . Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance. J Clin Invest. 1987;80(1):33–40
- . Mechanisms of response to treatment in autoimmune thrombocytopenic purpura. N Engl J Med. 1989;320(15):974–980
- AMG531, a thrombopoiesis-stimulating protein, for chronic ITP. N Engl J Med. 2006;355(16):1672–1681
- . Immunogenic studies of the platelet-specific PlA1 (Zwa). Immunobiology. 1982;160:375–381
- . Thrombocytopenia in term children: a population based study. Obstet Gynecol. 2000;95:441–446
- . Clinical and diagnostic comparison of neonatal alloimmune thrombocytopenia to non-immune cases of thrombocytopenia. Pediatr Blood Cancer. 2005;45(2):176–183
- . European Fetomaternal Alloimmune Thrombocytopenic Study Group. European collaborative study of the antenatal management of feto-maternal alloimmune thrombocytopenia. Br J Haematol. 2003;122(2):275–288
- Parallel randomized trials of risk-based therapy for fetal alloimmune thrombocytopenia. Obstet Gynecol. 2006;107(1):91–96
- . Alloimmune thrombocytopenia: state of the art 2006. American Journal of Obstet Gynecol. 2006;195(4):907–913
- . Neonatal thrombocytopenia: incidence and characterization of maternal antiplatelet antibodies by MAIPA assay. Br J Haematol. 1998;100:735–740
- Antenatal management of alloimmune thrombocytopenia: a randomized trial in fifty-five maternal-fetal pairs. Am J Obstet Gynecol. 1996;174:1414–1423
- . Isoimmune neonatal thrombocytopenia purpura: Clinical and therapeutic considerations. Blood. 1964;23:154–157
- . Intraventricular hemorrhage and its prognosis, prevention and treatment in term infants. J Trop Pediatr. 1999;45:237–240
- . CNS lesions in neonatal isoimmune thrombocytopenia. Arch Neurol. 1983;40:552–554
- . Cerebral hemorrhage in alloimmune thrombocytopenia. Pediatr Radiol. 1995;25:444–445
- . Fetal diagnosis and management of neonatal alloimmune thrombocytopenia. Semin Perinatol. 1997;21:45–52
- . Antepartum fetal intracranial hemorrhage, predisposing factors and prenatal sonography: a review. Am J Perinatol. 1998;7:431–441
- . Neonatal alloimmune thrombocytopenia: antenatal and postnatal imaging findings in the pediatric brain. Am J Neuroradiol. 2002;23(9):1457–1465
- . Favorable neurological outcome in seven cases of perinatal intracranial hemorrhage due to immune thrombocytopenia. Am J Pediatr Hematol Oncol. 1991;13:156–159
- . Devastating sequelae of alloimmune thrombocytopenia: an entity that deserves more attention. J Matern Fetal Med. 1996;5:137–141
- . Severe fetomaternal alloimmune thrombocytopenia presenting with fetal hydrocephalus. Prenat Diagn. 1996;16:1152–1155
- . Intracranial hemorrhage in utero as a complication of isoimmune thrombocytopenia. J Pediatr. 1979;95:611–614
- . In utero cerebral hemorrhage in alloimmune thrombocytopenia. Am J Pediatr Hematol Oncol. 1986;8:312–317
- . Intracranial hemorrhage in utero due to isoimmune neonatal thrombocytopenia. Obstet Gynecol. 1985;65(suppl):20–21
- . Neonatal alloimmune thrombocytopenic purpura and congenital porencephaly in two siblings associated with a “new” maternal antiplatelet antibody. Blood. 1985;65:1412–1415
- . Intracranial hemorrhage in utero re. Thrombocytopenia [Letter]. J Pediatr. 1980;97:695–696
- . Acquired disorder of platelet function associated with autoantibodies against membrane glycoprotein Iib-IIIa complex. Thromb Haemost. 1991;65:491–496
- . Prospective evaluation of a new platelet glycoprotein (GP)-specific assay (PakAuto) in the diagnosis of autoimmune thrombocytopenia (AITP). Am J Hematol. 2005;78(3):193–197
- . Fetal bleeding in neonatal alloimmune thrombocytopenia mediated by anti-PLA1 is not associated with inhibition of fibrinogen binding to platelet GPIIb/IIIa. Am J Clin Pathol. 1995;103:636–641
- . Effect of maternal anti-HPA-1a antibodies and polyclonal IVIG on the activation status of vascular endothelial cells. Clin Exp Immunol. 2004;137(1):216–222
- Analysis of immunoglobulin class, IgG subclass and titre of HPA-1a antibodies in alloimmunized mothers giving birth to babies with or without neonatal alloimmune thrombocytopenia. Br J Haematol. 1994;87:813–817
- . Immunoglobulin G subclass of anti-human platelet antigen 1a in maternal sera: relation to the severity of neonatal alloimmune thrombocytopenia. Eur J Haematol. 1997;59:287–292
- . Prenatal diagnosis of neonatal alloimmune thrombocytopenia using allele-specific oligonucleotide probes. Blood. 1991;78:2276–2282
- Rapid determination of platelet alloantigen genotyped by polymerase chain reaction using allele-specific primers. Transfusion. 1994;34:955–960
- . Antenatal genotyping of the blood groups of the fetus. Vox Sang. 1998;74(Suppl. 2):365–374
- . Genotyping for human platelet antigen-1 directly from dried blood spots on cards. Blood. 1996;88:3242–3243
- . A whole blood assay for platelet HPA-1 (PLA1) phenotyping applicable to large scale antenatal screening. Br J Haematol. 1996;92:221–225
- . An international trial demonstrates suitability of a newly developed whole-blood ELISA kit from multicentre platelet HPA-1 phenotyping. Vox Sang. 1999;77:103–106
- . Human platelet antigen genotyping using a fluorescent SSCP technique with an automatic sequencer. British Journal of Haematology. 1998;103:437–444
- . Monoclonal antibody-specific immobilization of platelet antigens (MAIPA): a new tool for the identification of platelet-reactive antibodies. Blood. 1987;70:1722–1726
- . Modification of the MAIPA technique to detect and identify anti-platelet glycoprotein auto-antibodies. Platelets. 1994;5:285
- . Comparison of the direct platelet immunoflurescence test (direct PIFT) with a modified direct monoclonal antibody-specific immobilization of platelet antigens (direct MAIPA) in detection of platelet-associated IgG. Br J Haematol. 1997;96:204–209
- . Monitoring anti-HPA-1a platelet antibody levels during pregnancy using the MAIPA test. Vox Sang. 1995;68:27–34
- . A simplified method for large-scale HPA-1a phenotyping for antenatal screening. Transfus Med. 1994;4:21–25
- . Identifying babies with neonatal alloimmune thrombocytopenia and the responsible antigens. Transfusion. 2007;47(1):6–7
- Alloimmune thrombocytopenia: fetal and neonatal losses related to cordocentesis. Am J Obstet Gynecol. 1995;172(2 Pt1):475–479
- . Long-term effects of fetal and neonatal alloimmune thrombocytopenia and its antenatal treatment on the medical and developmental outcomes of affected children. Am J Perinatol. 2006;23(8):487–492
- . Management of isoimmune neonatal thrombocytopenia. Am J Obstet Gynecol. 1976;124:39–42
- . The management of the pregnant patient with idiopathic thrombocytopenic purpura. Am J Obstet Gynecol. 1976;126:449–451
- . Failure of cesarean section to prevent intracranial hemorrhage in siblings with isoimmune thrombocytopenia. Am J Obstet Gynecol. 1985;153:79–81
- . Immune thrombocytopenic purpura in pregnancy: a reappraisal of management. Obstet Gynecol. 1991;78:578–583
- Percutaneous umbilical blood sampling: indication changes and procedure loss rate in a nine years’ experience. Fetal Diagn Ther. 1996;11:106–113
- . Cordocentesis using the combined technique: needle guide-assisted and free-hand. Fetal Diagn Ther. 1997;12:252–254
- . Fetal blood sampling—indication-related losses. Prenat Diagn. 1998;18:934–940
- . Cordocentesis at 16–24 weeks of gestation: experience of 1.320 cases. Prenat Diagn. 2000;20:224–228
- . Cordocentesis: an appraisal of risks. Am J Obstet Gynecol. 1988;159:1497–1500
- . Serial aggressive platelet transfusion for fetal alloimmune thrombocytopenia: platelet dynamics and perinatal outcome. Am J Obstet Gynecol. 2002;186:826–831
- . Will it ever be possible to balance the risk of intracranial hemorrhage in fetal or neonatal alloimmune thrombocytopenia against the risk of treatment strategies to prevent it?. Vox Sang. 2003;84(4):318–325
- Antenatal noninvasive treatment of patients at risk for alloimmune thrombocytopenia without a history of intracranial hemorrhage. Am J Obstet Gynecol. 2006;195(4):1153–1157
- . The management of feto-maternal alloimmune thrombocytopenia: report of three cases. J Matern Fetal Neonatal Med. 2006;19(8):517–520
- . A less invasive treatment strategy to prevent intracranial hemorrhage in fetal and neonatal alloimmune thrombocytopenia. Am J Obstet Gynecol. 2001;185(3):683–688
- . Intravenous immunoglobulins without initial and follow-up cordocentesis in alloimmune fetal and neonatal thrombocytopenia at high risk for intracranial hemorrhage. Fetal Diagn Ther. 2006;21(1):55–60
- . Initial fetal platelet counts predict the response to intravenous gammaglobulin therapy in fetuses that are affected by PLA1 incompatibility. Am J Obstet Gynecol. 2001;185(4):976–980
- . Antenatal treatment of neonatal alloimmune thrombocytopenia. N Engl J Med. 1988;319:1374–1378
- . Antenatal treatment of alloimmune thrombocytopenia. Obstet and Gynecol. 1992;80:67–71
- . Failure of antenatal high-dose immunoglobulin to improve fetal platelet count in neonatal alloimmune thrombocytopenia. Vox Sang. 1988;55:188–189
- Continuing controversy in alloimmune thrombocytopenia: fetal hyperimmunoglobulin fails to prevent thrombocytopenia. Am J Obstet Gynecol. 1990;163:1144–1146
- Maternal intravenous immunoglobulin treatment does not prevent intracranial hemorrhage in fetal alloimmune thrombocytopenia. Transfus Med. 1994;4:293–296
- Prenatal treatment of alloimmune thrombocytopenia. Lancet. 1984;2:632
- . Management of alloimmune thrombocytopenia: antenatal diagnosis and in utero transfusion of maternal platelets. Blood. 1988;72:340–343
- . In utero platelet transfusion for alloimmune thrombocytopenia [Letter]. Lancet. 1988;2:506
- Antenatal management of fetomaternal alloimmune thrombocytopenia-report of 15 affected pregnancies. Transfus Med. 1994;4:281–292
- . Feto-maternal alloimmune thrombocytopenia: antenatal therapy with IvIgG and steroids–more questions than answers. European Working Group on FMAIT. Br J Haematol. 1998;100(1):62–65
- . Follow up of children after antenatal treatment for alloimmune thrombocytopenia. Early Hum Dev. 2004;80(1):65–76
- . The immunologic profile of infants born after maternal immunoglobulin treatment and intrauterine platelet transfusions for fetal/neonatal alloimmune thrombocytopenia. Am J Obstet Gynecol. 2004;191(3):815–820
- Fetal and neonatal thrombopoietin levels in alloimmune thrombocytopenia. Pediatr Res. 2002;52(1):105–108
- . Longitudinal thrombopoietin plasma concentrations in fetuses with alloiumune thrombocytopenia treated with intrauterine PLT transfusions. Transfusion. 2003;43(9):1216–1222
- . Use of “compatible” platelet transfusions in treatment of congenital isoimmune thrombocytopenic prupura. N Engl J Med. 1969;280:244–247
- Antigen-positive platelet transfusion in neonatal alloimmune thrombocytopenia (NAIT). Blood. 2006;107(9):3761–3763
- . Advances in the management of alloimmune thrombocytopenia. Br J Haematol. 2007;136(3):366–378
- . When are platelets just platelets?. Blood. 2006;107(9):3426–3427
- . Survey of the use and clinical effectiveness of HPA-1a/5b-negative platelet concentrates in proven or suspected platelet alloimmunization. Transfus Med. 2004;14(6):409–417
- . The treatment of neonatal isoimmune thrombocytopenia with intravenous immunoglobin (IgG i.v.). Blut. 1984;48:383–386
- . Intravenous immunoglobulin for neonatal isoimmune thrombocytopenia. Arch Dis Child. 1985;60:667–669
- . Intravenous immunoglobulin in neonatal isoimmune thrombocytopenia. J Pediatr. 1987;111:133–135
- . Working Party on Neonatal Immune Thrombocytopenia of the Neonatal Hemostasis Subcommittee of the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis: Recommendations for the evaluation and treatment of neonatal autoimmune and alloimmune thrombocytopenia. Thromb and Haemost. 1991;65:631–634
- . A second case of neonatal alloimmune thrombocytopenia associated with anti-PLA2 (Zwb) antibodies. Haematologia. 1989;22:109–113
- . A case of severe neonatal thrombocytopenia with schizencephaly associated with anti-HPA-1b and antiHPA-2a. Br J Haematol. 1994;87:576–579
- Neonatal thrombocytopenia in HLA-DR, -DQ, -DP-typed mother due to rare anti-HPA-1b (anti-PLA2) (Zwb) fetomaternal immunization. Vox Sang. 1994;67:45–51
- . Anti-HPA-1b really causes neonatal alloimmune thrombocytopenia. Br J Haematol. 1995;89:428
- . Neonatal alloimmune thrombocytopenia due to anti-HPA-1b (PLA2) (Zwb). Vox Sang. 1998;74:256–259
- . Baka, a new platelet-specific antigen involved in neonatal allo-immune thrombocytopenia. Vox Sang. 1980;39:113–120
- . A new platelet-specific alloantigen Br(a): Report of 4 cases with neonatal alloimmune thrombocytopenia. Vox Sang. 1988;54:101–106
- . A new platelet alloantigen Tua, on glycoprotein IIIa associated with neonatal alloimmune thrombocytopenia in two families. Br J Haematol. 1993;83:306–310
- . Neonatal alloimmune thrombocytopenia due to a new platelet-specific alloantibody. Blood. 1993;81:3318–3323
PII: S0268-960X(07)00053-7
doi: 10.1016/j.blre.2007.09.002
© 2007 Elsevier Ltd. All rights reserved.
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Blood Reviews
Volume 22, Issue 1
, Pages 33-52
, January 2008
