Blood Reviews
Volume 22, Issue 6 , Pages 311-320, November 2008

Induction therapy for elderly patients with acute myeloid leukemia

Section of Bone Marrow Transplantation and Leukemia, Division of Medical Oncology, Siteman Cancer Center, Washington University in Saint Louis, MO 63110, United States

published online 09 June 2008.

Summary 

Acute myeloid leukemia (AML) is a disease of older adults. Efforts to intensify therapy along traditional avenues have failed to yield improved results. There remains significant clinical equipoise as to how to “induce” patients and whether or not 7+3-style regimens improve outcomes over low-dose cytarabine. What is certain is that even in those not receiving active therapy, AML is an exceptionally morbid disease. Diverse interventions are being explored in the management of older patients with AML and the currently available data will be reviewed.

Keywords: Acute myeloid leukemia, Review, Induction therapy, Elderly

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PII: S0268-960X(08)00039-8

doi:10.1016/j.blre.2008.04.004

Blood Reviews
Volume 22, Issue 6 , Pages 311-320, November 2008

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