« Previous
Blood Reviews
Volume 23, Issue 2
, Pages 87-93
, March 2009
Lenalidomide in combination with dexamethasone for the treatment of relapsed or refractory multiple myeloma
References
- . Towards a new age in the treatment of multiple myeloma. Ann Hematol. 2007;86:159–172
- Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc. 2003;78:21–33
- National Comprehensive Cancer Network®. NCCN Clinical Practice Guidelines in OncologyTM. Multiple Myeloma. V.1.2008. <www.nccn.org/professionals/physician_gls/PDF/myeloma.pdf> [accessed 4.10.2007].
- . UK Myeloma Forum; Nordic Myeloma Study Group; British Committee for Standards in Haematology. Guidelines on the diagnosis and management of multiple myeloma 2005. Br J Haematol. 2006;132:410–451
- . Thalidomide and lenalidomide in the treatment of multiple myeloma. Eur J Cancer. 2006;42:1612–1622
- . The evolving role of lenalidomide in the treatment of hematologic malignancies. Expert Opin Pharmacother. 2007;8:497–509
- . The evolution of thalidomide and its IMiD derivatives as anticancer agents. Nat Rev Cancer. 2004;4:314–322
- Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood. 2002;100:3063–3067
- Richardson P, Jagannath S, Hussein M, et al. A multicenter, single-arm, open-label study to evaluate the efficacy and safety of single-agent lenalidomide in patients with relapsed and refractory multiple myeloma; preliminary results. Blood (ASH Annual Meeting Abstracts) 2005; 106: [Abstract 1565].
- A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma. Blood. 2006;108:3458–3464
- . Lenalidomide in multiple myeloma. Expert Rev Anticancer Ther. 2006;6:1165–1173
- For the Multiple Myeloma-009 Study Investigators. Oral lenalidomide plus dexamethasone for relapsed/refractory multiple myeloma. N Eng J Med. 2007;357:2133–2142
- For the Multiple Myeloma-010 Study Investigators. Lenalidomide plus dexamethasone versus dexamethasone alone for relapsed or refractory multiple myeloma. N Eng J Med. 2007;357:2123–2132
- . Recent clinical studies of the immunomodulatory drug (IMiD®) lenalidomide. Br J Cancer. 2005;93:613–619
- A randomized phase 3 trial of oral lenalidomide and dexamethasone versus placebo and dexamethasone in patients with relapsed or refractory multiple myeloma. Final analysis of MM010 study. Haematologica. 2007;92(s2):[Abstract PO-661]
- Celgene Corporation, 2005. Revlimid® prescribing information. <www.revlimid.com/pdf/REVLIMID_PI.pdf> [accessed 4.10.2007].
- Chen C, Reece DE, Siegel D, et al. Expanded access program (EAP) for lenalidomide (Revlimid®) plus dexamethasone in over 1400 subjects with relapsed or refractory multiple myeloma. Blood (ASH Annual Meeting Abstracts) 2006; 108: [Abstract 3556].
- Long-term results of response to therapy, time to progression, and survival with lenalidomide plus dexamethasone in newly diagnosed myeloma. Mayo Clin Proc. 2007;82:1179–1184
- Weber D, Wang M, Chen C, et al. Lenalidomide plus high-dose dexamethasone provides improved overall survival compared to high-dose dexamethasone alone for relapsed or refractory multiple myeloma (MM): results of 2 phase III studies (MM-009, MM-010) and subgroup analysis of patients with impaired renal function. Blood (ASH Annual Meeting Abstracts) 2006; 108: [Abstract 3547].
- Thalidomide- and lenalidomide-associated thromboembolism among patients with cancer. JAMA. 2006;296:2558–2560
- . Lenalidomide and venous thrombosis in multiple myeloma. N Engl J Med. 2006;354:2079–2080
- . Lenalidomide and venous thrombosis in multiple myeloma. N Engl J Med. 2006;354:2079–2080
- Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma. Blood. 2005;106:4050–4053
- Rajkumar SV, Jacobus S, Callander N, et al. Phase III trial of lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone in newly diagnosed multiple myeloma (E4A03): A trial coordinated by the Eastern Cooperative Oncology Group. J Clin Oncol (ASCO Annual Meeting Abstracts) 2007; 25 (June 20 Suppl.): [Abstract LBA8025].
- . Dermatologic adverse effects of lenalidomide therapy for amyloidosis and multiple myeloma. Arch Dermatol. 2006;142:1298–1302
- Lenalidomide in combination with dexamethasone is more effective than dexamethasone at first relapse in relapsed multiple myeloma. Blood (ASH Annual Meeting Abstracts). 2006;108:[Abstract 3552]
- Chanan-Khan AA, Yu Z, Weber D, et al. Lenalidomide (L) in combination with dexamethasone (D) significantly improves time to progression (TTP) in non-stem cell transplant patients (pts) with relapsed or refractory (rel/ref) multiple myeloma (MM): analysis from MM-009 and MM-010 randomized phase III clinical trials. Blood (ASH Annual Meeting Abstracts) 2006; 108: [Abstract 3554].
- Effect of Len/Dex in MM despite Thal resistance. Haematologica. 2007;92(s2):[Abstract PO-662]
- Bahlis NJ, Mansoor A, Lategan JC, et al. Lenalidomide overcomes poor prognosis conferred by deletion of chromosome 13 and t(4;14) in multiple myeloma: MM016 trial. Blood (ASH Annual Meeting Abstracts) 2006; 108: [Abstract 3557].
- . Patterns of survival in multiple myeloma: a population-based study of patients diagnosed in Sweden from 1973 to 2003. J Clin Oncol. 2007;25:1993–1999
- Chanan-Khan AA, Weber D, Dimopoulos M, et al. Lenalidomide (L) in combination with dexamethasone (D) improves survival and time to progression in elderly patients (pts) with relapsed or refractory (rel/ref) multiple myeloma (MM). Blood (ASH Annual Meeting Abstracts) 2006; 108: [Abstract 3551].
- Effect of Len/Dex in MM in different age groups. Haematologica. 2007;92(s2):[Abstract PO-663]
- Pharmacokinetics of lenalidomide in subjects with various degrees of renal impairment and in subjects on hemodialysis. J Clin Pharmacol. 2007;47:1466–1475
- US Food and Drug Administration. Information on Erythropoiesis Stimulating Agents (ESA). <www.fda.gov/cder/drug/infopage/RHE/default.htm> [accessed 8.1.2008].
- . Therapeutic options for the treatment of cancer-associated thrombosis. Semin Oncol Nurs. 2005;21(4 Suppl 1):21–40
- Thalidomide and deep vein thrombosis in multiple myeloma: risk factors and effect on survival. Clin Lymphoma. 2003;4:32–35
- . Monoclonal gammopathy of undetermined significance and multiple myeloma are associated with an increased incidence of venothromboembolic disease. Cancer. 2004;101:558–566
- . Risk factors for chemotherapy-associated venous thromboembolism in a prospective observational study. Cancer. 2005;104:2822–2829
- . Thromboembolism in hospitalized neutropenic cancer patients. J Clin Oncol. 2006;24:484–490
- Increased risk of thrombosis with lenalidomide in combination with dexamethasone and erythropoietin. J Clin Oncol (ASCO Annual Meeting Abstracts). 2006;24:(June 20 Suppl.): [Abstract 7506]
- The role of aspirin in the prevention of thrombotic complications of thalidomide and anthracycline-based chemotherapy for multiple myeloma. Mayo Clin Proc. 2005;80:1568–1574
- Lenalidomide and pegylated liposomal doxorubicin-based chemotherapy for relapsed or refractory multiple myeloma: safety and efficacy. Ann Oncol. 2006;17:1766–1771
- High incidence of thrombotic events observed in patients receiving lenalidomide (L) + dexamethasone (D) (LD) as first-line therapy for multiple myeloma (MM) without aspirin (ASA) prophylaxis. Blood (ASH Annual Meeting Abstracts). 2005;106:[Abstract 3455]
- . Thromboembolism risk reduction in multiple myeloma patients treated with immunomodulatory drug combinations. Thromb Haemost. 2006;95:924–930
- . Bleeding risks of antithrombotic therapy. BMJ. 2002;325:828–831
- Comparison of low-molecular-weight heparin and warfarin for the secondary prevention of venous thromboembolism in patients with cancer: a randomized controlled study. Arch Intern Med. 2002;162:1729–1735
- Randomized comparison of low-molecular-weight heparin versus oral anticoagulant therapy for the prevention of recurrent venous thromboembolism in patients with cancer (CLOT) Investigators. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med. 2003;349:146–153
- . Meta-analysis: low-molecular-weight heparin and bleeding in patients with severe renal insufficiency. Ann Intern Med. 2006;144:673–684
- . Prophylactic antibiotics for the prevention of early infection in multiple myeloma. Am J Med. 1996;100(6):624–628
- . Hypersensitivity pneumonitis-like syndrome associated with the use of lenalidomide. Chest. 2007;131:1572–1574
- Oral melphalan at diagnosis hampers adequate collection of peripheral blood progenitor cells in multiple myeloma. Haematologica. 2002;87:846–850
- Impact of lenalidomide therapy on stem cell mobilization and engraftment post-peripheral blood stem cell transplantation in patients with newly diagnosed myeloma. Leukemia. 2007;21:2035–2042
- National Comprehensive Cancer Network®. NCCN Clinical Practice Guidelines in OncologyTM. Cancer-Related Fatigue. V.4.2007. <www.nccn.org/professionals/physician_gls/PDF/fatigue.pdf> [accessed 4.10.2007].
PII: S0268-960X(08)00063-5
doi: 10.1016/j.blre.2008.07.003
© 2008 Elsevier Ltd. All rights reserved.
« Previous
Blood Reviews
Volume 23, Issue 2
, Pages 87-93
, March 2009
