Blood Reviews
Volume 23, Issue 4 , Pages 143-147 , July 2009

Assessment and management of high-risk pregnancies in women with thrombophilia

References 

  1. Brenner B, Blumenfeld Z. Thrombophilia and fetal loss. Blood Rev. 1997;11:72–79
  2. Bremme K. Haemostasis in normal pregnancy. In: Women’s issues in thrombosis and hemostasis. London: Martin Dunitz Ltd.; 2002;p. 151–165
  3. Rai R, Regan L. Recurrent miscarriage. Lancet. 2006;368:601–611
  4. Kupferminc MJ, Eldor A, Steinman N, et al. Increased frequency of genetic thrombophilia in women with complications of pregnancy. New Engl J Med. 1999;340:9–13
  5. Sarig G, Younis JS, Hoffman R, et al. Thrombophilia is common in women with idiopathic pregnancy loss and is associated with late pregnancy wastage. Fertil Steril. 2002;77:342–347
  6. Sanson BJ, Friederich PW, Simioni P, et al. The risk of abortion and stillbirth in antithrombin-, protein C-, and protein S-deficient women. Thromb Haemost. 1996;75:387–388
  7. Meinardi JR, Middeldorp S, de Kam PJ, et al. Increased risk for fetal loss in carriers of the factor V Leiden mutation. Ann Intern Med. 1999;130:736–739
  8. Robertson L, Wu O, Langhorne P, et al. The thrombosis: risk and economic assessment of thrombophilia screening (TREATS) study. Thrombophilia in pregnancy: a systematic review. Br J Haematol. 2006;132:171–196
  9. Ginsberg JS, Brill-Edwards P, Johnston M, et al. Relationship of antiphospholipid antibodies to pregnancy loss in patients with systemic lupus erythematosus: a cross-sectional study. Blood. 1992;80:859–862
  10. Sebire NJ, Regan L, Rai R. Biology and pathology of the placenta in relation to antiphospholipid antibody-associated pregnancy failure. Lupus. 2002;11:641–643
  11. Rai R, Regan L. Obstetric complications of antiphospholipid antibodies. Curr Opin Obstet Gynecol. 1997;9:387–390
  12. Kist WJ, Janssen NG, Kalk JJ, et al. Thrombophilias and adverse pregnancy outcome - A confounded problem!. Thromb Haemost. 2008;99:77–85
  13. Brenner B, Hoffman R, Blumenfeld Z, et al. Gestational outcome in thrombophilic women with recurrent pregnancy loss treated by enoxaparin. Thromb Haemost. 2000;83:693–697
  14. Carp H, Dolitzky M, Inbal A. Thromboprophylaxis improves the live birth rate in women with consecutive recurrent miscarriages and hereditary thrombophilia. J Thromb Haemost. 2003;1:433–438
  15. Gris JC, Mercier E, Quere I, et al. Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. Blood. 2004;103:3695–3699
  16. Brenner B, Hoffman R, Carp H, et al. LIVE-ENOX investigators. Efficacy and safety of two doses of enoxaparin in women with thrombophilia and recurrent pregnancy loss: the LIVEENOX study. J Thromb Haemost. 2005;3:227–229
  17. Rey E, Kahn SR, David M, et al. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet. 2003;361:901–908
  18. Martinelli I, Taioli E, Cetin I, et al. Mutations in coagulation factors in women with unexplained late fetal loss. New Engl J Med. 2000;343:1015–1018
  19. Bates SM, Greer IA, Pabinger I, et al. Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians evidence-based clinical practice guidelines (8th ed.). Chest. 2008;133:844S–886S
  20. Kher A, Bauersachs R, Nielsen JD. The management of thrombosis in pregnancy: role of low-molecular-weight heparin. Thromb Haemost. 2007;97:505–513
  21. Bates SM. Management of pregnant women with thrombophilia or a history of venous thromboembolism. Hematol Am Soc Hematol Educ Program. 2007;143–150
  22. Hirsh J, Levine MN. Low molecular weight heparin. Blood. 1992;79:1–17
  23. Sarig G, Blumenfeld Z, Leiba R, et al. Modulation of systemic hemostatic parameters by enoxaparin during gestation in women with thrombophilia and pregnancy loss. Thromb Haemost. 2005;94:980–985
  24. Vignoli A, Marchetti M, Balducci D, et al. Differential effect of the low-molecular-weight heparin, dalteparin, and unfractionated heparin on microvascular endothelial cell hemostatic properties. Haematologica. 2006;91:207–214
  25. Greer IA, Nelson-Piercy C. Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy. Blood. 2005;106:401–407
  26. Lepercq J, Conard J, Borel-Derlon A, et al. Venous thromboembolism during pregnancy: a retrospective of enoxaparin safety in 624 pregnancies. Br J Obstet Gynaecol. 2001;108:1134–1140
  27. Sanson BJ, Lensing AW, Prins MH, et al. Safety of low molecular weight heparin in pregnancy: a systemic review. Thromb Haemost. 1999;81:668–672
  28. Brenner B, Bar J, Ellis M, et al. LIVE-ENOX investigators. Effects of enoxaparin on late pregnancy complications and neonatal outcome in women with recurrent pregnancy loss and thrombophilia: results from the LIVE-ENOX study. Fertil Steril. 2005;84:770–773
  29. Laposata M, Green D, Van Cott EM, et al. College of American Pathologists Conference XXXI on laboratory monitoring of anticoagulant therapy: the clinical use and laboratory monitoring of low-molecular-weight heparin, danaparoid, hirudin and related compounds, and argatroban. Arch Pathol Lab Med. 1998;122(9):799–807
  30. The Columbus Investigators . Low-molecular-weight heparin in the treatment of patients with venous thromboembolism. New Engl J Med. 1997;337(10):657–662
  31. Sephton V, Farquharson RG, Topping J, et al. A longitudinal study of maternal dose response to low molecular weight heparin in pregnancy. Obstet Gynecol. 2003;101:1307–1311
  32. Bounameaux H, de Moerloose P. Is laboratory monitoring of low-molecular-weight heparin therapy necessary? No. J Thromb Haemost. 2004;2(4):551–554
  33. Gyamfi C, Cohen R, Desancho MT, et al. Prophylactic dosing adjustment in pregnancy based upon measurements of anti-factor Xa levels. J Matern Fetal Neonatal Med. 2005;18:329–331
  34. Fox NS, Laughon SK, Bender SD, et al. Anti-factor Xa plasma levels in pregnant women receiving low molecular weight heparin thromboprophylaxis. Obstet Gynecol. 2008;112:884–889

PII: S0268-960X(08)00082-9

doi: 10.1016/j.blre.2008.11.001

Blood Reviews
Volume 23, Issue 4 , Pages 143-147 , July 2009