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Blood Reviews
Volume 22
, Pages S35-S41
, December 2008
Long-term efficacy and safety of deferasirox
References
-
.
The design of orally active iron chelators
.
Ann NY Acad Sci
. 2005;1054:141–154
-
.
Iron-chelating therapy and the treatment of thalassaemia
.
Blood
. 1997;89:736–761
-
Deferoxamine (Desferal®) package insert. Novartis 2002.
-
.
Secondary iron overload
.
Hematology Am Soc Hematol Educ Program
. 2001;47–61
-
Deferiprone (Ferriprox®) package insert. Apotex Europe Ltd. 1999.
- A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassaemia . Blood . 2006;107:3455–3462
-
Deferasirox (Exjade®) package insert. Novartis 2005.
-
.
In:
Iron overload. Guidelines for the Clinical Management of Thalassaemia
. 2nd Ed.. Cyprus: Nicosia; 2007;p. 31–63
- . Combined therapy with deferiprone and desferrioxamine . Br J Haematol . 1998;106:252–253
-
Deferiprone: new insight
.
Ann NY Acad Sci
. 2005;1054:169–174
- Deferiprone or deferoxamine vs. combination therapy in patients with beta-thalassemia major: a case study in Taiwan . Hemoglobin . 2006;30(1):125–130
- . Effective combination therapy of deferiprone and deferoxamine for the rapid clearance of excess cardiac iron and the prevention of heart disease in thalassaemia. The Protocol of the International Committee on Oral Chelators . Hemoglobin . 2006;30:239–249
- . Combined therapy with desferrioxamine and deferiprone in beta thalassaemia major patients with transfusional iron overload . Ann Hematol . 2006;85:315–319
- Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients . Br J Haematol . 2003;121:187–189
-
.
Comparative efficacy of desferrioxamine, deferiprone and in combination on iron chelation in thalassemic children
.
Indian J Pediatr
. 2004;41:21–27
-
A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patients with thalassaemia
.
Haematologica
. 2006;91:1241–1243
- A randomized controlled 1-year study of daily deferiprone plus twice weekly desferrioxamine compared with daily deferiprone monotherapy in patients with thalassaemia major . Haematologica . 2007;92:1599–1606
-
A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassaemia major using cardiovascular magnetic resonance
.
Circulation
. 2007;115:1876–1884
-
Combined chelation therapy in thalassaemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction
.
J Cardiovasc Magn Reson
. 2008;25:12
-
Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassaemia patients with transfusional iron overload
.
Haematologica
. 2006;91:873–880
-
Phase II clinical evaluation of deferasirox, a once-daily oral chelating agent, in paediatric patients with beta-thalassaemia major
.
Haematologica
. 2006;91:1343–1351
- . Effect of transfusional iron intake on response to chelation therapy in beta-thalassaemia major . Blood . 2008;111:583–587
- Prospective evaluation of patient-reported outcomes during treatment with deferasirox or deferoxamine for iron overload in patients with beta-thalassaemia . Clin Ther . 2007;29:909–917
- A randomised comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell disease . Br J Haematol . 2007;136:501–508
- Patient-reported outcomes of deferasirox (Exjade(R), ICL670) versus deferoxamine in sickle cell disease patients with transfusional hemosiderosis. Substudy of a randomized open-label phase II trial . Acta Haematol . 2008;119:133–141
-
Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study
.
Eur J Haematol
. 2008;80:168–176
-
Deferasirox (ICL670; Exjade®) reduces serum ferritin (SF) and labile plasma iron (LPI) in patients with myelodysplastic syndromes (MDS)
.
Blood
. 2007;110:
abstract 1470.
-
Evaluation of deferasirox (Exjade®, ICL670) therapy in patients with transfusional iron overload who achieve serum ferritin (SF) (less than or equal to) 1000 ng/mL in long-term studies
.
Blood
. 2007;110:
abstract 3795.
-
Long-term treatment with deferasirox (Exjade®, ICL670), a once-daily oral iron chelator, is effective in patients with transfusion-dependent anaemias
.
Blood
. 2007;110:
abstract 2777.
-
Impact of dose adjustments on serum ferritin (SF) levels during long-term treatment with once-daily, oral deferasirox (Exjade®, ICL670)
.
Blood
. 2007;110:
abstract 2778.
-
Long-term efficacy and safety with deferasirox (Exjade®, ICL670), a once-daily oral iron chelator, in paediatric patients
.
Blood
. 2007;110:
abstract 2774.
-
Long-term efficacy and safety of deferasirox (Exjade®, ICL670), a once-daily oral iron chelator, in patients with sickle cell disease (SCD)
.
Blood
. 2007;110:
abstract 3395.
- . Results of long-term iron-chelating therapy . Acta Haematol . 1996;95:26–36
- Survival in medically treated patients with homozygous beta-thalassaemia . N Engl J Med . 1994;331:574–578
- Hepatic iron concentration combined with long-term monitoring of serum ferritin to predict complications of iron overload in thalassaemia major . Br J Haematol . 2000;110:971–977
-
Survival and complications in patients with thalassaemia major treated with transfusion and deferoxamine
.
Haematologica
. 2004;89:1187–1193
PII: S0268-960X(08)70007-9
doi: 10.1016/S0268-960X(08)70007-9
© 2008 Elsevier Ltd. All rights reserved.
« Previous
Blood Reviews
Volume 22
, Pages S35-S41
, December 2008
