Blood Reviews
Volume 23, Issue 5 , Pages 199-204 , September 2009

Umbilical cord blood transplantation: Pros, cons and beyond

  • Anfisa Stanevsky

      Affiliations

    • Hematology Division, Chaim Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    • ,
  • Gal Goldstein

      Affiliations

    • Pediatric Hematooncology, Chaim Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    • ,
  • Arnon Nagler

      Affiliations

    • Hematology Division, Chaim Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    • Cord Blood Bank, Chaim Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    • Corresponding Author InformationCorresponding author. Address: Hematology Division and CBB, Sheba Medical Center, 52621 Tel-Hashomer, Israel. Tel.: +972 3 5305830; fax: +972 3 5305377.

References 

  1. Gluckman E, Broxmeyer HA, Auerbah AD, et al. Hematopoietic reconstitution in a patient with Fanconi’s anemia by means of umbilical cord blood from an HLA-identical sibling. N Engl J Med. 1989;321:1174–1178
  2. Laporte JP, Corin NC, Rubinstein P, et al. Cord-blood transplantation from an unrelated donor in an adult with chronic myelogenous leukemia. N Engl J Med. 1996;18:167–170
  3. Bone Marrow Donors Worldwide, Annual report, 2008.
  4. Liu E, Law HK, Lau YL. Tolerance associated with cord blood transplantation may depend on the state of host dendritic cells. Br J Haematol. 2004;126:517–526
  5. Nitsche A, Zhang M, Clauss T, Siegert W, Brune K, Pahl A. Cytokine profiles of cord and adult blood leukocytes: differences in expression are due to differences in expression and activation of transcription factors. BMC Immunol. 2007;31:8–18
  6. Cohen SB, Madrigal JA. Immunological and functional differences between cord and peripheral blood. Bone Marrow Transplant. 1998;2(Suppl. 3):S9–S12
  7. Garderet L, Dulphy N, Douay C, Chalumeau N, Schaeffer V, Zilber MT, et al. The umbilical cord blood alphabeta T-cell repertoire: characteristics of a polyclonal and naïve but completely formed repertoire. Blood. 1998;91:340–346
  8. Dalle JH, Menezes J, Wagner E, Blaqdone M, Champaqne J, Champaqne MA, et al. Characterization of cord blood natural killer cells: implication for transplantation and neonatal infections. Pediatr Res. 2005;57:649–655
  9. Sullivan JM. Banking on cord blood stem cells. Nat Rev Cancer. 2008;
  10. Long GD, Laughlin M, Madan B, Kurtzberg J, Gasparetto C, Morris A, et al. Unrelated umbilical cord blood transplantation in adult patients. Biol Blood Marrow. 2003;9:772–780
  11. Wagner JE, Barker JN, DeFor TE, Baker KS, Blazar BR, Eide C, et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood. 2002;100:1611–1618
  12. Rubinstein P, Stevens CE. Placental blood for bone marrow replacement: the New York Blood Center’s program and clinical results. Baillieres Best Pract Res Clin Haematol. 2000;13:565–584
  13. Gluckman E, Rocha V, Chevret S. Results of unrelated umbilical cord blood hematopoietic transplantation. Rev Clin Exp Hematol. 2002;5:87–99
  14. Michel G, Rocha V, Chevret S, Arcese W, Chan KW, Filipovich A, et al. Unrelated cord blood donor transplantation for children with AML a Eurocord Group analysis. Blood. 2003;102:4290–4297
  15. Locatelli F, Rocha V, Chastang C, Arcese W, Michel G, Abecasis M, et al. Factors associated with outcome after cord blood transplantation in children with acute leukemia. Blood. 1999;93:3662–3885
  16. Laughlin MJ, Barker J, Bambach B, Koc ON, Rizzieri DA, Wagner JE, et al. Hematopoeitic engraftment and survival in adult recipients of umbilical cord blood from unrelated donors. N Engl J Med. 2001;344:1815–1822
  17. Laughlin MJ, Eapen M, Rubinstein P, Wagner JE, Zhang MJ, Champlin RE, et al. Outcome after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. NEJM. 2004;351:2265–2275
  18. Rocha V, Labopin M, Sanz G, Arcese W, Scellshwerdtfeger R, Bosi A, et al. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med. 2004;351:2276–2285
  19. Rocha V, Wagner JE, Sobocinski KA, et al. Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling. Eurocord and International Bone Marrow Transplant Registry Working Committee on Alternative Donor and Stem Cell Source. N Engl J Med. 2000;342:1846–1854
  20. Barker JN, Davies SM, DeFor T, Ramsay NK, Weisdorf DJ, Wagner JE. Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor bone marrow: results of a matched-pair analysis. Blood. 2001;97:2957–2961
  21. Rocha V, Cornish J, Sievers EL, et al. Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia. Blood. 2001;97:2962–2971
  22. Takahashi S, Ooi J, Iseki T, et al. Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies. Blood. 2004;104:3813–3820
  23. Gluckman E, Rosha V, et al. Donor selection for unrelated cord blood transplants. Curr Opin Immun. 2006;18:565–570
  24. Gluckman E, Rocha V, et al. Factors associated with outcome of unrelated cord blood transplant: guidelines for donor choice. Exp Hemat. 2004;32:397–407
  25. Dalle JH, Duval M, Moghrabi A, Wagner E, Vachon MF, Barrette S, et al. Results of an unrelated transplant search strategy using partially HLA-mismatched cord blood as an immediate alternative to HLA-matched bone marrow. Bone Marrow Transplant. 2004;33:605–611
  26. Hurley CK, Wagner JE, Setterholm MI, Confer DL. Advances in HLA: practical implications for selecting adult donors and cord blood units. Biol Blood Marrow Transplant. 2006;12:28–33
  27. Wall DA, Carter SL, Kernan NA, Kapoor N, Kamani NR, Brochstein JA, et al. Busulfan/melphalan/antithymocyte globulin followed by unrelated donor cord blood transplantation for treatment of infant leukemia and leukemia in young children: the cord blood transplantation study (COLBT) experience. Biol Blood Marrow Transplant. 2005;11:637–646
  28. Gluckman E, Koegler G, Rocha V. Human leukocyte matching in cord blood transplantation. Semin Hematol. 2005;42:85–90
  29. Gluckman E. The E. Donnall Thomas lecture. Cord blood transplantation. Biol Blood Marrow Transplant. 2006;12:808–812
  30. Kögler G, Enczmann J, Rocha V, Gluckman E, Wernet P. High resolution HLA typing by sequencing for HLA-A, B, C, Dr, DQ in 122 unrelated cord blood patient pairs transplants hardly improves long term clinical outcome. Bone Marrow Transplant. 2005;36:1033–1041
  31. Eapen M, Rubinstein P, Zhang MJ, Stevens C, Kurtzberg J, Scaradavou A, et al. Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet. 2007;369:1947–1954
  32. Takahashi S, Ooi J, Tomonari A, Konuma T, Tsukada N, Oiwa-Monna M, et al. Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regimen. Blood. 2007;109:1322–1330
  33. Locatelli F, Rocha V, Reed W, Bernaudin F, Ertem M, Grafakos S, et al. Related umbilical cord blood transplant in patient with thalassemia and sickle cell disease. Blood. 2003;101:2137–2143
  34. Bernaudin F, Socie G, Kuentz M, et al. Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease. Blood. 2007;110:2749–2756
  35. Gluckman E, Rocha V, Ionescu I, et al. Results of unrelated cord blood transplant in Fanconi anemia patients: risk factor analysis for engraftment and survival. Biol Blood Marrow Transplant. 2007;13:1073–1082
  36. Goldstein G, Bielorai B, Nagler A, Hutt D, Neuman Y, et al. Cord blood transplantation in children – a single institute experience. Bone marrow Transplant. 2005;35(Suppl. 2):S366
  37. Bielorai B, Hughes MR, Auerbach AD, Nagler A, Loewenthal R, Rechavi G, et al. Successful umbilical cord blood transplantation for Fanconi anemia using preimplantation genetic diagnosis for HLA-matched donor. Am J Hematol. 2004;77:397–399
  38. Howrey RP, Martin PL, Ciocci G. Unrelated cord blood transplantation for correction of genetic disease. Blood. 1998;92(Suppl.):291;[Abstract]
  39. Staba SL, Escolar ML, Poe M, Kim Y, Martin PL, Szabolcs P, et al. Cord-blood transplants from unrelated donors in patients with Hurler’s syndrome. N Engl J Med. 2004;350:1960–1969
  40. Stein J, Zion Garty B, Dror Y, Fenig E, Zeigler M, Yaniv I. Successful treatment of Wolman disease by unrelated umbilical cord blood transplantation. Eur J Pediatr. 2007;166:663–666
  41. Verneris MR, Brunstein CG, DeFor T, Barker J, Weisdorf DJ, Blazar BR, et al. Risk of relapse after umbilical cord blood transplantation in patients with acute leukemia: marked reduction in recipients of two units. ASH Annual Meeting Abstracts. 2005;106:305
  42. Del Toro G, Satwani P, Harrison L, Cheung YK, Brigid Bradley M, George D, et al. Pilot study of reduced intensity conditioning and allogeneic stem cell transplantation from unrelated cord blood and matched family donors in children and adolescellsent recipients. Bone Marrow Transplant. 2004;33:613–622
  43. Chao NJ, Koh LP, Long GD, Gasparetto C, Horwitz M, Morris A, et al. Adult recipients of umbilical cord transplants after nonmyeloablative preparative regiments. Biol Blood Marrow Transplant. 2004;10:569–575
  44. Yuji K, Miyakoshi S, Kato D, Miura Y, Myojo T, Murashige N, et al. Reduced-intensity unrelated cord blood transplantation for patients with advanced malignant lymphoma. Biol Blood Marrow Transplant. 2005;11:314–318
  45. Bradley MB, Satwani P, Baldinger L, Morris E, van de Ven C, Del Toro G, et al. Reduced intensity allogeneic umbilical cord blood transplantation in children and adolescent recipients with malignant and non-malignant diseases. Bone Marrow Transplant. 2007;40:621–631
  46. Brunstein CG, Barker JN, Weisdorf DJ, DeFor TE, Miller JS, Blazar BR, et al. Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease. Blood. 2007;110:3064–3070
  47. Magro E, Regidor C, Cabrera R, Sanjuán I, Forès R, Garcia-Marco JA, et al. Early hematopoietic recovery after single unit unrelated cord blood transplantation in adults supported by co-infusion of mobilized stem cells from a third party donor. Haematologica. 2006;91:640–648
  48. Frassoni F, Gualani F, et al. Direct intrabone transplant of unrelated cord-blood cells in acute leukemia: a phase I/II study. The Lancet Oncol. 2008;9:831–839
  49. Lewis I, Vefaillie CM. Multi-lineage expansion potential of primitive hematopoietic progenitors. Superiority of umbilical Cord blood compared to mobilized peripheral blood. Exp Hematol. 2000;28:1087–1095
  50. Shpall EJ, Quinones R, Giller R, Zeng C, Baron AE, Jones RB, et al. Transplantation of ex vivo expanded cord blood. Biol Blood Marrow Transplant. 2002;8:368–376
  51. de Lima M, McMannis J, Gee A, Komanduri K, Couriel D, Andersson BS, et al. Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a print phase I/II clinical trial. Bone Marrow Transplant. 2008;41:771–778
  52. Gesine Bug, Hilal Gül, Kerstin Schwarz, Heike Pfeifer, Manuela Kampfmann, Xiaomin Zheng, et al. Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells. Cancer Res. 2005;65:2537–2541
  53. Avello J, van de Ven C, Fortino W, et al. Characterization of cord blood natural killer and lymphokine activated killer lymphocytes following ex vivo cellular engineering. Biol Blood Marrow Transplant. 2006;12:608–622
  54. Wall DA, Chan KW. Selection of cord blood unit(s) for transplantation. Bone Marrow Transplant. 2008;1–7
  55. Tse William, Bunting Kevin D, Laughtin Mary J. New insights into cord blood stem cell transplantation. Curr Opin Hematol. 2008;15:279–284
  56. Kern S, Eichler H, Stoeve J, Klüter H, Bieback K. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells. 2006;24:1294–1301
  57. Li CD, Zhang WY, Li HL, Jiang XX, Zhang Y, Tang PH, et al. Mesenchymal stem cells derived from human placenta suppress allogeneic umbilical cord blood lymphocyte proliferation. Cell Res. 2005;15:539–547
  58. Le Blanc K, Samuelsson H, Gustafsson B, Remberger M, Sundberg B, Arvidson J, et al. Transplantation of mesenchymal stem cells to enhance engraftment of hematopoetic stem cells. Leukemia. 2007;21:1733–1738
  59. Tisato V, Naresh K, Girdlestone J, Navarrete C, Dazzi F. Mesenchymal stem cells of cord blood origin are effective at preventing but not treating graft-versus-host disease. Leukemia. 2007;21(Sep):1992–1999
  60. Secco M, Zucconi E, Vieira NM, Fogaça LL, Cerqueira A, Carvalho MD, et al. Multipotent stem cells from umbilical cord: cord is richer than blood!. Stem Cells. 2008;26:146–506
  61. Leor J, Guetta E, Feinberg MS, Galski H, Bar I, Holbova R, et al. Human umbilical cord blood-derived CD133+ cells enhance function and repair of the infracted myocardium. Stem cells. 2006;24:772–780
  62. Arien-Zakay H, Nagler A, Galski H, Lazarovici P. Neuronal conditioning medium and nerve growth factor induce neuronal differentiation of collagen – adherent progenitors derived from human umbilical cord blood. J Mol Neurosci. 2007;32:179–191
  63. Ma N, Ladilov Y, Kaminski A, Piechaczek C, Choi YH, Li W, et al. Umbilical cord blood cell transplantation for myocardial regeneration. Transplant Proc. 2006;38:771–773
  64. Ruvinov E, Sharabani-Yosef O, Nagler A, et al. Transplantation of genetically engineered cardiac fibroblasts producing recombinant human erythropoietin to repair the infracted myocardium. Fibrogenesis tissue Repair. 2008;1:7
  65. Condiotti R, Zakai YB, Nagler A. Ex vivo expansion of CD56+ cytotoxic cells from human umbilical cord blood. Exp Hematol. 2001;29:104–113
  66. Serrano LM, Pfeiffer T, Olivares S, et al. Differentiation of naïve cord blood T cells into CD19-specific cytolytic effectors for posttransplantation adoptive immunotherapy. Blood. 2006;107:2643–2652
  67. Miller JS, Brunstein CG, Cooley S, et al. A novel triple umbilical cord blood transplant (UCBT) strategy to promote NK cell immunotherapy (unit 1) with a fully ablative preparative regimen followed by a double UCBT in patients with refractory AML. Blood. 2006;108:3111
  68. Katia Perruccio, Antonella Tosti, et al. Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation. Blood. 2005;106:4397–4406

PII: S0268-960X(09)00017-4

doi: 10.1016/j.blre.2009.02.001

Blood Reviews
Volume 23, Issue 5 , Pages 199-204 , September 2009

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